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Biological Product (Except Diagnostic) Manufacturing

NAICS 325414 · Federal Contracts & Awards

USAspending.gov records $13,183,433,554.11 in Biological Product (Except Diagnostic) Manufacturing obligations for fiscal year 2025. That yearlyTrend amount is 49.0% of NAICS 325414's $26,909,109,940.38 extract-wide total — the companion year to this slice's FY2024 325414 cell, not a replacement for it. The pair is except-diagnostic biological manufacturing plus FY2025, not a lot census and not cash already paid. The extract publishes 1,274 325414 award records industry-wide. FY figures can be incomplete for the current year.

Key figures

  • USAspending records $13,183,433,554.11 in Biological Product (Except Diagnostic) Manufacturing FY2025 obligations (NAICS 325414).
  • That cell is 49.0% of the industry's $26,909,109,940.38 extract-wide total.
  • The FY2024 325414 cell on this slice is a different yearlyTrend row.
  • 1,274 is the industry extract award-record count, not a FY2025 contract census.

What the 325414–FY2025 join is

NAICS 325414 and fiscal year 2025 meet in one yearlyTrend cell. $13,183,433,554.11 is the obligation sum tagged to that pair. It is not the FY2024 325414 cell on this slice, not pharmaceutical preparation manufacturing (325412), and not an outlay. The two 325414 years share an industry extract; they do not share a yearlyTrend row.

A second-year cell beside a first-year cell can look like a decline or a rise. This page reports $13,183,433,554.11 as given for FY2025. Ranking years as winners or losers is not the join. Correlation with product news is not causation.

FY2025 beside the 325414 longer book

49.0% of $26,909,109,940.38 landed in this cell. The FY2024 325414 pair on this slice is a different row. Adding that row into $13,183,433,554.11 would double-count. The industry hub at /industries/325414/ is the parent without a FY2025 filter. FY2025 federal spending at /fiscal-years/2025/ is the parent without a 325414 filter.

An open fiscal year can restated later. Cite $13,183,433,554.11 as obligations, not as payments already cleared on a named lot.

Full analysis: Biological Product (Except Diagnostic) Manufacturing federal obligations in FY2025 →

Questions

How much did biological product manufacturing obligate in FY2025?
USAspending.gov records $13,183,433,554.11 in Biological Product (Except Diagnostic) Manufacturing obligations for FY2025 under NAICS 325414. That yearlyTrend total is not an outlay and not the industry's $26,909,109,940.38 extract-wide sum. Keep Biological Product (Except Diagnostic) Manufacturing and FY2025 on the same citation as $13,183,433,554.11.
Is $13,183,433,554.11 the same as the FY2024 325414 cell?
No. FY2025 is 49.0% of NAICS 325414's $26,909,109,940.38 extract-wide total. The FY2024 325414 join is a separate yearlyTrend row. Do not substitute one year for the other. 1,274 is the industry extract award-record count, not a FY2025 headcount.
Do 1,274 awards mean 1,274 FY2025 biologic contracts?
No. 1,274 is the 325414 extract award-record count, not a FY2025-only census. The packet does not name makers. Obligations of $13,183,433,554.11 are not outlays. The pair is NAICS 325414 plus FY2025. The pair is NAICS 325414 plus FY2025.
Does this include outlays or campaign donations?
No. $13,183,433,554.11 is an obligation aggregate from USAspending.gov. Outlays are unpublished. FEC contribution tables do not fund these awards. USAspending.gov remains the source for NAICS 325414 in FY2025. The pair is NAICS 325414 plus FY2025.

USAspending.gov NAICS yearlyTrend by fiscal year. Obligations are not outlays. FY figures can be incomplete for the current year.

Industry ties

All data ties →

Companies in the Biological Product (Except Diagnostic) Manufacturing industry (NAICS code 325414) have received $26.91B in federal contracts, grants, and other awards since FY2024, across 1K individual awards tracked through FY2026. The largest funding agency is Department of Health and Human Services ($11.40B). Spending is concentrated in New York, Massachusetts, Maryland and 45 other states. All figures below come from USAspending.gov award records.

Total Obligations

$26.91B

Total Awards

1K

States

48

Last Updated

Apr 17, 2026

Yearly Spending Trend

Top 50 Awards in Biological Product (Except Diagnostic) Manufacturing

Largest individual obligations in NAICS 325414.

Download CSV
Top 50 Awards in Biological Product (Except Diagnostic) Manufacturing
AwardRecipientAwarding AgencyProgramPlaceFYObligation
CONT_AWD_W15QKN21C0012_9700_-NONE-_-NONE-
DEOBLIGATION IN SUPPORT OF CLOSEOUT.
PFIZER INC
New York
Department of Defense
Department of the Army
—NEW YORK, NY-122025$11,110,134,066
CONT_AWD_W58P0521C0002_9700_-NONE-_-NONE-
CORONAVIRUS DISEASE 2019 (COVID-19) GLOBAL VACCINE MISSION
PFIZER INC
New York
Agency for International Development
Agency for International Development
—NEW YORK, NY-122024$4,150,835,100
CONT_AWD_75A50120C00034_7505_-NONE-_-NONE-
THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (HHS), OFFICE OF THE ASSISTANT SECRETARY FOR PREPAREDNESS AND RESPONSE (ASPR), BIOMEDICAL ADVANCED RESEARCH AND DEVELOPMENT AUTHORITY (…
MODERNATX, INC.
Massachusetts
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—CAMBRIDGE, MA-072024$1,754,345,480
CONT_IDV_75D30119D04518_7523
2019 VACCINES FOR CHILDREN
MERCK SHARP & DOHME LLC
New Jersey
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$1,667,184,877
CONT_IDV_HHSD200201800361I_7523
VACCINES FOR CHILDREN
MERCK SHARP & DOHME LLC
New Jersey
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$1,516,055,054
CONT_IDV_75D30123D16111_7523
VACCINES FOR CHILDREN
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$841,136,855
CONT_AWD_75A50119C00071_7505_-NONE-_-NONE-
ACAM2000, SMALLPOX (VACCINIA) VACCINE, LIVE (ACAM)
EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC.
Maryland
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—GAITHERSBURG, MD-062024$748,857,151
CONT_IDV_75A50120D00002_7505
THE PURPOSE OF THIS MODIFICATION IS TO: 1) REVISE THE ATTACHMENT 0001 - INCENTIVE FEE MILESTONE SCHEDULE FOR CLINS 0002 AND 0004 PER EMAIL DATED APRIL 28, 2025. 2) FOR CLIN 0…
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
——2025$612,225,077
CONT_IDV_75D30121D10576_7523
VACCINES FOR CHILDREN
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Centers for Disease Control and Prevention
——2025$560,454,087
CONT_IDV_75D30122D13471_7523
VACCINES FOR CHILDREN
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$485,293,086
CONT_IDV_75D30120D07514_7523
VACCINES FOR CHILDREN
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$386,756,388
CONT_AWD_75A50124F61002_7505_75A50123D00003_7505
OTA: THE PURPOSE OF THIS MODIFICATION IS TO INCREASE THE TOTAL ESTIMATED COST AND ADD FUNDING.
ADVANCED TECHNOLOGY INTERNATIONAL
South Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—SUMMERVILLE, SC-012024$303,999,997
CONT_AWD_75A50424F64001_7505_75A50123D00003_7505
OT: THE PURPOSE OF THIS MODIFICATION IS TO ADMINISTRATIVELY UPDATE ATTACHMENT 1, SECTION 7. TASK ORDER POINTS OF CONTACT
ADVANCED TECHNOLOGY INTERNATIONAL
South Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—WASHINGTON, DC-982024$248,500,001
CONT_AWD_HHSO100200600013C_7505_-NONE-_-NONE-
CLOSE CONTRACT AND DEOBLIGATE EXCESS FUNDS
DYNPORT VACCINE COMPANY LLC
Maryland
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—FREDERICK, MD-062025$235,119,971
CONT_AWD_75A50124F61005_7505_75A50123D00003_7505
OT: THE PURPOSE OF THIS MODIFICATION IS TO ADMINISTRATIVELY UPDATE ATTACHMENT 1, SECTION 7. TASK ORDER POINTS OF CONTACT.
ADVANCED TECHNOLOGY INTERNATIONAL
South Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—SUMMERVILLE, SC-012024$141,320,194
CONT_AWD_HHSO100201100012C_7505_-NONE-_-NONE-
CLOSE CONTRACT AND DEOBLIGATE EXCESS FUNDS. THE FINAL INVOICE/VOUCHER NUMBER E001045480 IN THE AMOUNT OF $7,500,000 DATED FEBRUARY 19, 2020, WAS MADE PER THE SETTLEMENT AGREEMENT.
NOVAVAX INC
Maryland
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—ROCKVILLE, MD-062025$121,393,966
CONT_IDV_HHSD200201800015I_7523
MOD TO ADD FUNDS TO PURCHASE PEDIATRIC VACCINE
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$104,899,072
CONT_AWD_75A50121C00009_7505_-NONE-_-NONE-
THE PURPOSE OF THIS MODIFICATION IS CLOSEOUT THIS CONTRACT
MERCK SHARP & DOHME LLC
New Jersey
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—DURHAM, NC-042024$102,299,549
CONT_IDV_75D30120D07115_7523
2020-2021 PEDIATRIC FLU SANOFI
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$102,105,604
CONT_IDV_HHSO100200600015I_7505
DEOBLIGATION OF EXCESS FUNDS
ROCHE LABORATORIES INC.
New Jersey
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
——2025$98,153,222
CONT_IDV_75D30124D18412_7523
PEDIATRIC FLU VACCINES 2024-2025
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$88,344,227
CONT_AWD_HHSO100201100011C_7505_-NONE-_-NONE-
CLOSE CONTRACT AND DEOBLIGATE EXCESS FUNDS
VAXINNATE CORPORATION
New Jersey
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—CRANBURY, NJ-122025$86,180,679
CONT_IDV_75D30122D12999_7523
PEDIATRIC FLU VACCINES 2022-2023
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$80,283,218
CONT_AWD_HHSO100200600011C_7505_-NONE-_-NONE-
CONTRACT CLOSEOUT DEOBLIGATE EXCESS FUNDS
GLAXOSMITHKLINE HOLDINGS (AMERICAS) INC.
Pennsylvania
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—PHILADELPHIA, PA-032025$72,766,564
CONT_AWD_75A50424F64002_7505_75A50123D00003_7505
OT: THE PURPOSE OF THIS MODIFICATION IS TO ADMINISTRATIVELY UPDATE ATTACHMENT 1, SECTION 7. TASK ORDER POINTS OF CONTACT
ADVANCED TECHNOLOGY INTERNATIONAL
South Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—SUMMERVILLE, SC-012024$61,000,000
CONT_AWD_75A50125C00002_7505_-NONE-_-NONE-
MAINTAINING OF EMBRYONATED EGG SUPPLY FOR NON-SEASONAL PRODUCTION OF PANDEMIC VACCINE
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—SWIFTWATER, PA-082025$53,212,199
CONT_IDV_75D30120D07116_7523
ADULT FLU 2020-2021 SEQIRUS
SEQIRUS USA INC
New Jersey
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$51,782,038
CONT_AWD_75A50124F61004_7505_75A50123D00003_7505
OT: THE PURPOSE OF THIS MODIFICATION IS TO UPDATE ATTACHMENT #1, SECTION 7. TASK ORDER POINTS OF CONTACT.
ADVANCED TECHNOLOGY INTERNATIONAL
South Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—SUMMERVILLE, SC-012024$50,679,329
CONT_AWD_HHSO10033005T_7505_HHSO100201600006I_7505
CLOSEOUT OF THIS EXPIRED TASK ORDER.
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—SWIFTWATER, PA-082024$40,642,758
CONT_IDV_75D30124D18414_7523
PEDIATRIC FLU VACCINES 2024-2025
SEQIRUS USA INC
New Jersey
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$40,176,661
CONT_AWD_75A50124F61003_7505_75A50123D00003_7505
OT: THE PURPOSE OF THIS MODIFICATION IS TO ADMINISTRATIVELY UPDATE ATTACHMENT 1, SECTION 7 TASK ORDER POINTS OF CONTACT.
ADVANCED TECHNOLOGY INTERNATIONAL
South Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—SUMMERVILLE, SC-012024$38,000,006
CONT_IDV_75D30120D07114_7523
2020-2021 ADULT FLU SANOFI
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Centers for Disease Control and Prevention
——2025$37,187,948
CONT_AWD_75A50124F61001_7505_75A50123D00003_7505
OT: THE PURPOSE OF THIS MODIFICATION IS TO EXTEND THE PERIOD OF PERFORMANCE.
ADVANCED TECHNOLOGY INTERNATIONAL
South Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—SUMMERVILLE, SC-012024$32,000,000
CONT_AWD_75A50122F61004_7505_75A50122D00004_7505
THE PURPOSE OF THIS TASK ORDER IS FOR THE ACQUISITION OF INFLUENZA A/ASTRAKHAN/3212/2020 (H5N8) VIRUS VACCINE CANDIDATE AND CLINICAL TRIAL.
SEQIRUS INC
North Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—HOLLY SPRINGS, NC-042024$30,739,088
CONT_AWD_75A50120F33010_7505_HHSO100201600005I_7505
CLOSEOUT OF TASK ORDER.
PROTEIN SCIENCES CORP
Connecticut
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—MERIDEN, CT-052024$29,925,884
CONT_IDV_75D30118D01508_7523
2018 ADULT VACCINES
GLAXOSMITHKLINE, LLC
North Carolina
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$28,792,553
CONT_AWD_HHSD200201794412C_7523_-NONE-_-NONE-
2017 ADULT VACCINES
MERCK SHARP & DOHME LLC
New Jersey
Department of Health and Human Services
Centers for Disease Control and Prevention
—WHITEHOUSE STATION, NJ-072024$20,935,014
CONT_AWD_HHSO10033008T_7505_HHSO100201200015I_7505
CLOSEOUT OF EXPIRED TASK ORDER AND CHANGE CONTRACTING OFFICER TO DEVIN FITZMAURICE.
SANOFI VACCINES US INC.
Pennsylvania
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—SWIFTWATER, PA-082024$20,628,300
CONT_AWD_HHSO10033015T_7505_HHSO100201200014I_7505
ACQUISITION OF MCMS FOR PANDEMIC INFLUENZA PREPAREDNESS AND RESPONSE
SEQIRUS INC
North Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—EMERYVILLE, CA-122025$20,539,764
CONT_IDV_HHSO100200600016I_7505
DEOBLIGATION OF EXCESS FUNDS
GLAXOSMITHKLINE HOLDINGS (AMERICAS) INC.
Pennsylvania
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
——2025$19,737,801
CONT_AWD_75A50124F61007_7505_75A50123D00003_7505
OTA AWARD FOR BIOMAP TASK ORDER #7 FOR CBRN AVAT_MABS
ADVANCED TECHNOLOGY INTERNATIONAL
South Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—SUMMERVILLE, SC-012024$19,620,884
CONT_AWD_HHSO10033024T_7505_HHSO100201200014I_7505
TO CLOSE THIS CONTRACT IN LINE WITH FAR 4.804, TO UPDATE THE CONTRACTING OFFICER TO DEVIN FITZMAURICE, AND TO DE-OBLIGATE $57,834.53 IN EXCESS FUNDS SO THE TOTAL OBLIGATION IS NOW…
SEQIRUS INC
North Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—HOLLY SPRINGS, NC-042025$18,890,210
CONT_AWD_75A50124F61010_7505_75A50122D00004_7505
SERVICES FOR H5 PANDEMIC READINESS FOR ACQUISITION OF MEDICAL COUNTERMEASURES (MCMS) FOR PANDEMIC INFLUENZA AND EMERGING DISEASES PREPAREDNESS AND RESPONSE, UNDER CONTRACT 75A5012…
SEQIRUS INC
North Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—HOLLY SPRINGS, NC-042024$18,790,750
CONT_IDV_75D30122D13001_7523
PEDIATRIC FLU VACCINES 2022-2023
SEQIRUS USA INC
New Jersey
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$18,527,344
CONT_IDV_75D30120D07117_7523
2020-2021 PEDIATRIC FLU SEQIRUS
SEQIRUS USA INC
New Jersey
Department of Health and Human Services
Centers for Disease Control and Prevention
——2024$18,245,201
CONT_AWD_75A50119F33009_7505_HHSO100201600004I_7505
THE PURPOSE OF THIS MODIFICATION IS TO EXTEND THE PERIOD OF PERFORMANCE OF GSK?S CONTRACT #HHSO10020160004I TASK ORDER 75A50119F33009; FROM 8/28/2019-2/28/2024 TO 8/28/2019-4/30/…
GLAXOSMITHKLINE, LLC
North Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—DURHAM, NC-042024$18,161,554
CONT_AWD_75A50124F61006_7505_75A50123D00003_7505
OT: THE PURPOSE OF THIS MODIFICATION IS TO ADMINISTRATIVELY UPDATE ATTACHMENT 1, SECTION 7. TASK ORDER POINTS OF CONTACT
ADVANCED TECHNOLOGY INTERNATIONAL
South Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—SUMMERVILLE, SC-012024$16,379,368
CONT_AWD_SPE2DP24F7574_9700_SPE2DP23D0004_9700
8510869772!JAPANESE ENCEPHALIT
VALNEVA USA, INC.
Maryland
Department of Defense
Defense Logistics Agency
—BETHESDA, MD-082024$16,016,000
CONT_AWD_HHSO10033004T_7505_HHSO100201600004I_7505
UPDATE CONTRACTING OFFICER, CLOSEOUT CONTRACT PER FAR 4.804
GLAXOSMITHKLINE, LLC
North Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—DURHAM, NC-042024$15,769,590
CONT_AWD_75A50124F61008_7505_75A50122D00004_7505
THE PURPOSE OF THIS TASK ORDER IS TO PROCURE SERVICES FOR STORAGE AND STABILITY VACCINE BULK LOTS FROM PRIOR CONTRACTS FOR DEPARTMENT OF HEALTH AND HUMAN SERVICES UNDER IDIQ CONTR…
SEQIRUS INC
North Carolina
Department of Health and Human Services
Office of Assistant Secretary for Preparedness and Response
—HOLLY SPRINGS, NC-042024$14,848,415

Top 50 awards shown, ranked by obligated amount. Dates reflect performance period; last-modified dates match USAspending.gov. Complete listings include all transaction history going back to FY2024.

Spending by State

Federal spending in the Biological Product (Except Diagnostic) Manufacturing industry (NAICS 325414) broken down by state, with obligated amounts and award counts.
StateFundingAwards
New York$15.26B48
Massachusetts$1.76B85
Maryland$1.19B154
South Carolina$663.0M8
Pennsylvania$290.1M88
North Carolina$273.9M53
District of Columbia$266.6M34
New Jersey$154.7M38
California$42.1M228
Connecticut$33.4M8
Ohio$23.8M21
Georgia$19.3M32
Wisconsin$11.6M40
New Hampshire$10.2M6
Texas$5.8M16
Missouri$4.3M31
Washington$3.7M26
Colorado$3.3M12
Maine$3.0M6
Oklahoma$3.0M5
Louisiana$2.5M6
Mississippi$2.2M8
Vermont$2.2M2
Virginia$2.1M24
Indiana$1.9M14
Illinois$794K24
Delaware$631K18
Tennessee$404K2
Nebraska$382K7
Montana$375K4
Utah$281K21
Kentucky$171K2
Minnesota$163K12
New Mexico$105K3
Arkansas$93K2
Florida$82K4
North Dakota$70K2
U.S. Virgin Islands$47K1
Alaska$47K1
Iowa$31K6
Michigan$30K5
Rhode Island$29K1
Arizona$23K2
Kansas$21K1
Idaho$20K1
Alabama$19K1
Wyoming$13K1
Nevada$01